Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436).
產品描述
該RHOA ELISA Kit (Rat)的產品描述請參考該產品的說明書
產品特點
ELISA試劑盒
保存建議
2°C to 8°C|-20°C
其他
Aviva Systems Biology總部位于加利福尼亞州圣迭戈，在中國北京設有辦公室，專注于為研究需求提供多克隆和單克隆抗體、ELISA試劑盒、蛋白質和定制服務。Aviva Systems Biology生產了24,000種經過驗證的多克隆抗體，并提供近20,000種ELISA試劑盒，定制實驗室服務包括蛋白表達和純化、抗體開發，以及ELISA的開發、驗證和生產。Aviva Systems Biology為與獨特物種和靶標相關的研究提供獨特工具，研究領域包括轉錄因子、癌癥、心血管、細胞生物學、DNA損傷和修復、表觀遺傳學、信號轉導、細胞分化、干細胞生物學等等。
