- 中文名稱
Beclin-1 多克隆抗體
- 英文名字
- Beclin-1 polyclonal antibody
- 供應商
- Viva Bioscience
- 產品貨號
- VB3166-50
- 產品報價
- ￥4375/50ug
- 產品說明書
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- 購買方式
- 產品新聞
- 背景資料
- Beclin-1, the mammalian orthologue of yeast Atg6, has a central role in autophagy. It interacts with a number of cofactors to regulate the lipid kinase VPS34 protein and promote formation of Beclin-1-VPS34-p150 core complexes, thereby inducing autophagy. During phagophore formation, the Vps34 complex contains Atg14L, whereas during maturation into an autolysosome in mammals the complex includes UVRAG. Additional modulating proteins in mammalian cells include AMBRA1, BIF1, RUBICON and HMGB1.
The BH3 domain of Beclin-1 is bound to, and inhibited by Bcl-2 or Bcl-XL. This interaction can be disrupted by phosphorylation of Bcl-2 and Beclin-1, or ubiquitination of Beclin-1. In addition, caspase-mediated cleavage of Beclin-1 promotes crosstalk between apoptosis and autophagy. Beclin-1 dysfunction has been implicated in many disorders, including cancer and neurodegeneration.
- 應用類型
- 免疫原
- Peptide derived from N-terminal region of human beclin-1 protein
- 來源宿主
- 反應性
- 保存建議
- 其他
- ?
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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