Background:
Autophagy involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs its substrates and delivers them to the lysosome for degradation. In many cases control of substrate selectivity is mediated by ubiquitin modification.
Atg9 transport:
Atg9 is the primary transmembrane Atg protein required for autophagosome formation. It is detected in multiple discrete puncta, which probably mark the donor membranes for phagophore expansion. Anterograde movement of Atg9 to the site of vesicle formation, the PAS in yeast, requires Atg11, Atg23 and Atg27. Retrograde movement of Atg9 back to the donor sites involves the Atg1
應用類型
免疫原
Peptide derived from C-terminus of human Atg9A protein
