BAP1 (BRCA1 Associated Protein 1) is a ubiquitin C-terminal hydrolase (UCH) that interacts with the RING finger domain of the tumour suppressor, ubiquitin E3 ligase BRCA1. It has been demonstrated that BAP1 and BRCA1 associate in vivo and have overlapping sub-nuclear localization patterns, indicating BAP1 plays a key role in regulating the BRCA1 growth control pathway via its deubiquitinating activity.
Recombinant human BAP1 protein expressed with a N-terminal His-tag.
