Recombinant human Otubain-1 protein expressed with a N-terminal His-tag.
Otubain-1 belongs to the ovarian tumor (OTU) domain class of cysteine protease deubiquitinating enzymes and has been implicated in mediating lymphocyte antigen responsiveness and may be generally involved in RNA processing and cell adhesion/morphology. Human otubain-1 has been shown to exhibit high linkage-specificity in vitro, cleaving K48-linked polyubiquitin but not K63-, K29-, K6-, or K11-linked polyubiquitin, or linear
