- 中文名稱
UBE2S 蛋白(人) (GST標簽)
- 英文名字
- UBE2S protein(human) (GST tag)
- 供應商
- Viva Bioscience
- 產品貨號
- VB2530-100
- 產品報價
- ￥3250/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- UBE2S is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.
The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type.
K11-linked ubiquitin molecules are abundant in vivo and, as for K48-linked chains, are thought to be efficient signals for proteasomal degradation. The human anaphase-promoting complex (APC/C) has been shown to assemble K11 linkages on its substrates, utilizing the E2 conjugating enzymes Ube2C (UbcH10) and Ube2S in the process. This suggests a key role for K11-linked ubiquitin chains and Ube2S in cell cycle progression. Overexpression of Ube2S has been linked to tumour cell proliferation and metastasis through its effects on the pVHL-HIF pathway.
Recombinant protein expressed with N-terminal GST-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis and identification of substrate specific E2-E3 pairs.
- 序列
- Q16763
- 來源宿主
- 溶解建議
- 1 mg/mL
- 保存建議
- 其他
- ?
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
