UbcH10, also known as UBE2C, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.
The anaphase-promoting complex (APC) coordinates mitosis by sequentially promoting the degradation of key cell-cycle regulators via the ubiquitin-proteasome pathway, utilising UbcH10 and K11-linked polyubiquitin chain modification of substrate proteins. Following the degradation of its substrates, the APC catalyzes the auto-ubiquitination of UbcH10 resulting in its degradation and subsequent inactivation of the APC.
Aberrant performance or modulated cellular levels of UbcH10 or any of its associated components is likely to have significant consequences for cell cycle regulation. Indeed UbcH10 expression has been shown to be a valid indicator of the proliferative and aggressive status of thyroid carcinomas and its overexpression is thought to play a role ovarian carcinogenesis. In contrast expression levels of UbcH10 are extremely low in many normal cells.
Recombinant untagged human UbcH10 protein. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis, identification of substrate specific E2-E3 pairs and determination of E2 polyubiquitin linkage specificity.
