中文名稱

UbcH6 蛋白(人) (His標簽)

英文名字

UbcH6 protein(human) (His tag)

供應商

Viva Bioscience

產品貨號

VB2480-100

產品報價

￥3250/100ug

產品說明書

點擊查看

購買方式

產品新聞

背景資料

UbcH6, also known as UBE2E1, is a member of the ubiquitin E2 conjugating enzyme family, essential components of the ubiquitin cascade.

The selectivity of the ubiquitin cascade for a particular substrate protein relies on the interaction between the E2 conjugating enzyme (of which a cell contains relatively few) and an ubiquitin E3 ligase, of which over 600 have been identified to date. The specific E2-E3 pair required for ubiquitination of a particular substrate protein in vivo may also control the type of ubiquitin modification (mono-, multi-, poly-ubiquitin), the exact substrate lysine residue(s) to be modified and, in the case of polyubiquitination, the chain length and lysine linkage type.

UbcH6 is a tumour suppressor candidate which also modulates the transcriptional repression activity of Ataxin-1, the gene product of Spinocerebellar ataxia type 1 (SCA1). SCA1 is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration, which is caused by expansion of the polyglutamine tract in Ataxin-1. UbcH6 has also be shown to act as an E2 conjugating enzyme for ISG15.

Recombinant human UbcH6 protein expressed with a N-terminal His-tag. Protein has utility in ubiquitination reactions, polyubiquitin chain synthesis, identification of substrate specific E2-E3 pairs and determination of E2 polyubiquitin linkage specificity.

序列

P51965

來源宿主

溶解建議

1 mg/mL

保存建議

其他

?

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

分享到：