- 中文名稱
Optineurin 多克隆抗體
- 英文名字
- Optineurin polyclonal antibody
- 供應商
- Viva Bioscience
- 產品貨號
- VB2410-50
- 產品報價
- ￥4500/50ug
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- Optineurin is an ubiquitin-binding protein implicated in the pathogenesis of glaucoma, that can function as an autophagic receptor at the crossroad between innate immunity and destruction of cytosolic pathogens by autophagy, a process also known as xenophagy.
Upon infection, most Salmonella are sequestered into Salmonella-containing vacuoles, SCVs, but some can escape from SCVs and proliferate in the cytosol. To prevent this, cytosolic bacteria are rapidly ubiquitinated, leading to the recruitment of several autophagic receptors including NDP52 and p62 as well as that of the TANK-binding kinase 1, TBK1. In response to bacterial products such as lipopolysaccharide (LPS), the pattern recognition receptor Toll-like receptor 4, TLR4, activates TBK1 leading to the phosphorylation of optineurin. Phosphorylated OPTN has a high affinity for the autophagic protein LC3, thereby physically bridging ubiquitinated bacteria to the autophagic machinery and allowing for their elimination by xenophagy.
- 應用類型
- 免疫原
- Peptide derived from human optineurin protein (a.a. 86-96)
- 來源宿主
- 反應性
- 保存建議
- 其他
- ?
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
-
