- 中文名稱
S5a 蛋白(人) (GST標簽)
- 英文名字
- S5a protein(human) (GST-tag)
- 供應商
- Viva Bioscience
- 產品貨號
- VB2284-100
- 產品報價
- ￥3250/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 產品新聞
- 背景資料
- S5a, also known as PSMD4, is a major ubiquitin binding protein that binds preferentially to polyubiquitin chains. It is found as a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome where it functions as a receptor for proteins destined for proteolytic degradation. In yeast, the homologue of S5a, Rpn10, is required for degradation of a subset of cellular proteins by the proteasome. Unlike other proteasome subunits, S5a exists predominantly as a free protein in the cytosol (i.e. not incorporated into the proteasome), though its precise role in the cytosol has yet to be fully elucidated.
S5a contains two approximately 15 amino acid ubiquitin interacting motifs (UIM) which are responsible for its binding to polyubiquitin chains. In vitro S5a binds predominantly to chains of at least four ubiquitins in length and can act as a substrate for a wide range of ubiquitin E3 ligases, which, it has been suggested, occurs by a novel mechanism involving the association of S5a with growing poly-Ub chains.
Recombinant human S5a protein expressed with a N-terminal GST-tag. Protein has utility in ubiquitin binding assays.
- 序列
- P55036
- 來源宿主
- 溶解建議
- 1 mg/mL
- 保存建議
- 其他
- ?
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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