Ganciclovir （GCV） is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
Ganciclovir is a synthetic analogue of 2’-deoxy-guanosine. It is initially phosphorylated to a deoxyguanosine triphosphate （dGTP） analogue. This mechanism competitively inhibits the integration of dGTP by viral DNA polymerase， resulting in the termination of elongation of viral DNA. Upon expression of a viral suicide gene encoding thymidine kinase， the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells， causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments.
Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.
序列
請咨詢我們客服或者請查看品牌官方網站
來源宿主
提供的【GCV】更昔洛韋Ganciclovir產品來源宿主，查看該產品說明書，或者在線咨詢我們。
溶解建議
Sterile Filtered White lyophilized （freeze-dried） powder. It is recommended to reconstitute the lyophilized Ganciclovir in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建議
Lyophilized Ganciclovir although stable at room temperature for 3 weeks， should be stored at 4℃.
