RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued-RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued代理/參數/廠家-細胞分析試劑盒-艾美捷科技有限公司

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中文名稱: RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued

英文名字: RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued

供應商: USBiological

產品貨號: R9399-01Y

產品報價: ￥1/250ul

產品說明書: 點擊查看

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產品描述: The 90kD ribosomal S6 kinases (RSK1-3) are a family of serine/threonine kinases broadly expressed in response to many growth factors, polypeptide hormones and neurotransmitters (1). p90RSK is activated by Erk1 and Erk2 in vitro and in vivo via phosphorylation (2). Several sites, such as Ser380, Thr359 and Ser363, are important for its activation (3). The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (4). p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro (5,6). DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to reduced interaction of p53 with its negative regulator, oncoprotein MDM2 (7). p38 MAP kinase controls cellular responses to cytokines and stress (8–11). Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light and growth factors (8–12). MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182. Growth factors and mitogens induce the activation of p70 S6 kinase, which in turn phosphorylates the S6 ribosomal protein. Phosphorylation of S6 correlates with an increase in translation, particularly of mRNAs with an oligopyrimidine tract in their 5' untranslated regions (13). This group of mRNAs (5'TOP) encodes proteins involved in cell cycle progression and proteins that are part of the translational machinery, such as ribosomal proteins and elongation factors (13,14).Applications: Suitable for use in ELISA and Western Blot. Other applications not tested.Recommended Dilution:Western Blot 1:200Optimal dilutions to be determined by the researcher.Storage and Stability:May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

產品特點: 針對RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued該產品的特點優勢，歡迎查閱官網提供的產品說明書。

保存建議: 建議收到RSK (90kD), p53, p38 MAPK, S6 Ribosomal Protein, phosphorylated, BioAssay Detection Kit discontinued產品后將其置于-20°C保存。

其他: Usbiological公司是美國著名的抗體和生化試劑供應商，生產世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細胞術等多種檢測方法。Usbiological公司現已擁有超過50,19234種抗體、抗原和生化產品，為科研用戶提供了諸多超值選擇。