sRAGE is a member of the immunoglobulin superfamily of cell surface molecules. sRAGE is a receptor for various molecules， including the amyloidogenic form of serum amyloid A， amyloid-beta protein， members of the S100/calgranulin superfamily and advanced glycation end products. sRAGE lies within the major histocompatibility complex （MHC） class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. sRAGE mediates interactions of nonenzymatic glycosylated proteins which accumulate in vascular tissue during aging & at an increasing rate in diabetes. sRAGE is a receptor for amyloid beta peptide.
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來源宿主
HEK293人胚腎上皮細胞中重組表達
溶解建議
Sterile Filtered White lyophilized （freeze-dried） powder. The sterile filtered concentrated （0.5mg/ml） protein solution was lyophilized with 50mM Tris-HCl pH-7.5 & 50mM NaCl. Add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely.
保存建議
Store lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4℃ for a limited period of time.
