Myelin Oligodendrocyte Glycoprotein is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization， it is a prime target antigen that plays a role in immune-mediated demyelination. Myelin Oligodendrocyte Glycoprotein is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG protein was found to differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia. MOG-specific antibody is crucial to the initiation of MOG-induced murine experimental autoimmune encephalomyelitis.
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來源宿主
大腸桿菌中重組表達
溶解建議
Sterile Filtered White lyophilized （freeze-dried） powder. The Myelin Oligodendrocyte Glycoprotein 0.5mg/ml solution was lyophilized from 20mM sodium acetate buffer pH-4 and 0.3M sodium chloride. It is recommended to reconstitute the lyophilized MOG in sterile 10mM Acetic acid not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建議
Lyophilized MOG although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution MOG should be stored at 4℃ between 2-7 days and for future use below
-18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
