Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity(ED =70 nM) relative to kringles 1-4(ED = 135 nM).
產品描述
Ang K1-3是含有259個氨基酸的單一非糖基化多肽鏈。代表一種含有前三個三環結構的纖溶酶原蛋白水解片段。血管緊張素K1-3減少內皮細胞增殖，并作為血管生成和腫瘤生長的有效抑制劑。相對于三環域1-4（ED = 135 nM），它顯示出增加的抑制活性（ED =70 nM）。
