- 中文名稱
用于開發夾心ELISA試劑盒,以測定細胞培養上清液、細胞裂解物、血清和血漿(肝素、EDTA)中的人IGFBP3。
- 英文名字
- For the development of sandwich ELISA kit to measure human IGFBP3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
- 供應商
- Nordic BioSite
- 產品貨號
- NDC-KBB-BLRDKB-5
- 產品報價
- ¥詢價/5plates

- 產品說明書
- 點擊查看
- 購買方式
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- 產品新聞

- 背景資料
- Insulin-like growth factor(IGF)-binding protein-3(IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers, and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene(IGFBP3) expression. Insulin-like growth factor-binding protein(IGFBP)-3, well characterized as the carrier of insulin-like growth factor(IGF), has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent, antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes. IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane, cytosol, or nuclear compartments and in the extrIGFBP-3llular matrix. IGFBP3 is also located on chromosome 7. The standard product used in this kit is recombinant human IGFBP-3, consisting of 265 amino acids with the molecular mass of 29kDa. As a result of glycosylation, the molecular mass is 41KDa.
- 產品描述
- 胰島素樣生長因子(IGF)結合蛋白-3(IGFBP-3)是IGF循環水平的主要決定因素,在臨床上可用于評估GH缺乏和預測GH治療的反應。IGFBP-3的循環水平與幾種常見癌癥的風險負相關,并且抗增殖劑如抗雌激素和類維生素A部分地通過上調IGFBP-3基因(IGFBP 3)表達而起作用。胰島素樣生長因子結合蛋白(IGFBP)-3是胰島素樣生長因子(IGF)的載體,具有與IGF結合無關的生物活性。IGFBP-3在未分化和早期分化的軟骨細胞中具有IGF非依賴性抗增殖作用,但在終末分化的軟骨細胞中沒有。IGFBP-3對細胞具有生長抑制和增強作用,這些作用不依賴于IGF作用,并通過特異性的。IGFBP-3結合蛋白/受體位于細胞膜、胞質溶膠或核區室以及IGFBP-3細胞外基質中。IGFBP 3也位于7號染色體上。本試劑盒使用的標準品為重組人IGFBP-3,由265個氨基酸組成,分子量為29 kDa。由于糖基化,分子量為41 KDa。
- 產品特點
- F-TESTO(游離睪酮)ELISA試劑盒
- 保存建議
- -20°C
- 其他
- Nordic BioSite(北歐生物) 總部位于瑞典,成立于1997年,旨在分銷研究和診斷領域的高質量和創新產品。 Nordic BioSite 被公認為整個北歐生物醫學研究和診斷產品領域的領導者。他們擁有超過570萬種的產品組合,代理了遍布歐洲和美國的頂級生物試劑制造商,是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外,Nordic BioSite 還擁有不斷增長的自產產品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產產品線(共26W+產品)。Nordic BioSite的產品類型主要是抗體,蛋白和試劑盒,產品適用范圍涵蓋15個不同的物種(人,牛,犬,鯰魚,雞,海豚,馬,貓,豚鼠,小鼠,綿羊,兔子,大鼠,豬和火雞),可為您提供一站式的生命科學研究解決方案~
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