- 中文名稱
用于開發夾心ELISA試劑盒,以測定細胞培養上清液、血清和血漿(肝素、EDTA、檸檬酸鹽)中的人纖連蛋白。
- 英文名字
- For the development of sandwich ELISA kit to measure human Fibronectin in cell culture supernatants, serum and plasma(heparin, EDTA, citrate).
- 供應商
- Nordic BioSite
- 產品貨號
- NDC-KBB-AN7OMY-5
- 產品報價
- ¥詢價/5plates

- 產品說明書
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- 購買方式
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- 產品新聞

- 背景資料
- Fibronectin(FN) also known as LETS, is identified on the surfFN of fibroblasts by labeling with radioactive compounds or specific antibodies. Fibronectin is a 430,000-dalton dimeric glycoprotein that exists in 2 forms, termed cellular and plasma fibronectin. Cellular and plasma fibronectins are heterodimers consisting of similar but not identical polypeptides. These two forms of FN differ in biologic activity. Fibronectins bind cell surfFNs and various compounds including collagen, fibrin, heparin, DNA, and actin. Because fibronectin stimulates endocytosis in several systems and promotes the clearance of particulate material from the circulation, it could function in the clearance of C1q-coated material such as immune complexes or cellular debris. Fibronectins are involved in cell adhesion, cell motility, opsonization, would healing, and maintenance of cell shape. LETS, encoded on chromosome 8, is responsible for the LETS protein expression in humans. Because LETS has been implicated in tumorigenicity and cellular transformation, it is of interest that rearrangement or modifications in the number of chromosome 8 have been associated with certain forms of cancer. The standard used in this kit is isolated from human plasma with the molecular mass of 200-250KDa.
- 產品描述
- 纖連蛋白(FN)也稱為LETS,通過用放射性化合物或特異性抗體標記而在成纖維細胞的surfFN上鑒定。纖連蛋白是一種430,000道爾頓的二聚糖蛋白,以兩種形式存在,稱為細胞纖連蛋白和血漿纖連蛋白。細胞和血漿纖連蛋白是由相似但不相同的多肽組成的異二聚體。這兩種形式的FN在生物活性上不同。纖連蛋白結合細胞表面FN和各種化合物,包括膠原、纖維蛋白、肝素、DNA和肌動蛋白。因為纖連蛋白刺激幾個系統中的內吞作用并促進顆粒物質從循環中的清除,所以它可以在清除C1 q包被的物質如免疫復合物或細胞碎片中起作用。纖連蛋白參與細胞粘附、細胞運動、調理作用、傷口愈合和細胞形狀的維持。LETS編碼于8號染色體,負責LETS蛋白在人體中的表達。因為LETS與致瘤性和細胞轉化有關,所以8號染色體數目的重排或修飾與某些形式的癌癥有關是令人感興趣的。本試劑盒所用標準品分離自人血漿,分子量為200- 250 KDa。
- 產品特點
- 人CD3d(分化抗原3d)ELISA試劑盒
- 保存建議
- -20°C
- 其他
- Nordic BioSite(北歐生物) 總部位于瑞典,成立于1997年,旨在分銷研究和診斷領域的高質量和創新產品。 Nordic BioSite 被公認為整個北歐生物醫學研究和診斷產品領域的領導者。他們擁有超過570萬種的產品組合,代理了遍布歐洲和美國的頂級生物試劑制造商,是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外,Nordic BioSite 還擁有不斷增長的自產產品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產產品線(共26W+產品)。Nordic BioSite的產品類型主要是抗體,蛋白和試劑盒,產品適用范圍涵蓋15個不同的物種(人,牛,犬,鯰魚,雞,海豚,馬,貓,豚鼠,小鼠,綿羊,兔子,大鼠,豬和火雞),可為您提供一站式的生命科學研究解決方案~
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