- 中文名稱
Rabbit IgG polyclonal antibody for CDC25B detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.
- 英文名字
- Rabbit IgG polyclonal antibody for CDC25B detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.
- 供應商
- Nordic BioSite
- 產品貨號
- NDC-ABB-MF508V-100
- 產品報價
- ￥詢價/100ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Central to the onset of mitosis in all eukaryotic cells is the CDC2 protein kinase, the activity of which is negatively regulated by phosphorylation and positively activated by dephosphorylation. The latter function is carried out by a specific phosphatase, CDC25. At least 3 human CDC25 genes code for the A, B, and C forms of CDC25. CDC25B is mapped to 20p13. P38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation. Inhibition of p38 blocks the rapid initiation of this checkpoint in both human and murine cells after ultraviolet radiation. In vitro, p38 binds and phosphorylates CDC25B at serines 309 and 361, and CDC25C at serine-216; phosphorylation of these residues is required for binding to 14-3-3 proteins. In vivo, inhibition of p38 prevents both phosphorylation of CDC25B at serine-309 and 14-3-3 binding after ultraviolet radiation, and mutation of this site is sufficient to inhibit the checkpoint initiation. Regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation.
- 應用類型
- ELISA,FC,WB
- 免疫原
- E.coli-derived human CDC25B recombinant protein (Position: M1-H486).
- 來源宿主
- rabbit
- 反應性
- human,mouse,rat
- 保存建議
- -20
- 其他
- Nordic BioSite(北歐生物) 總部位于瑞典，成立于1997年，旨在分銷研究和診斷領域的高質量和創新產品。 Nordic BioSite 被公認為整個北歐生物醫學研究和診斷產品領域的領導者。他們擁有超過570萬種的產品組合，代理了遍布歐洲和美國的頂級生物試劑制造商，是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外，Nordic BioSite 還擁有不斷增長的自產產品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產產品線(共26W+產品)。Nordic BioSite的產品類型主要是抗體，蛋白和試劑盒，產品適用范圍涵蓋15個不同的物種(人，牛，犬，鯰魚，雞，海豚，馬，貓，豚鼠，小鼠，綿羊，兔子，大鼠，豬和火雞)，可為您提供一站式的生命科學研究解決方案~
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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