- 中文名稱
腺苷脫氨酶（ADA1）抑制劑篩選試劑盒（比色）
- 英文名字
- Adenosine Deaminase (ADA1) Inhibitor Screening Kit (Colorimetric)
- 供應商
- Biovision
- 產品貨號
- K993-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- Adenosine Deaminase (ADA, E.C. 3.5.4.4.) is an enzyme that catalyzes the conversion of adenosine and 2’-deoxyadenosine to inosine and 2’-deoxyinosine. Adenosine is a metabolite that plays important roles in determining cell proliferation, cell cycle progression, and immunosuppressive activation. Although multiple pathways exist for the production of adenosine, its deamination is irreversible, and becomes a critical point in purine metabolite signaling. Both adenosine and inosine bind the adenosine A2A receptor yet can trigger different downstream signaling. Excess adenosine in penile tissue contributes to the disorder called priapism, and impaired adenosine signaling is associated with erectile dysfunction. For this reason, substantial work has gone into identification of inhibitors that would be of clinical relevance. The major isoform of adenosine deaminase, ADA1, is widely expressed in most cells in humans, particularly in lymphocytes and macrophages. ADA1 is present in the cytosol, nucleus and found associated with dipeptidyl peptidase-4 on the cell membrane while ADA2 was first found in the spleen but is predominantly found in the plasma and serum. Adenosine signaling is part of the immune response, and has been shown to reduce T-cell activation. Adenosine Deaminase activity is thus a marker for T-lymphocyte proliferation. BioVision’s Adenosine Deaminase (ADA1) Inhibitor Screening Kit includes the larger 41 kDa form, human ADA1. In BioVision’s ADA inhibitor screening kit, adenosine is deaminated by ADA1 forming inosine. This intermediate is converted to uric acid by a series of enzymatic reactions. The formed uric acid can be measured in the supplied U.V. transparent plate at OD 293 nm. A highly specific ADA1 inhibitor is included as a positive control for inhibition. The kit provides a rapid, simple, sensitive, and reliable test, suitable for high-throughput screening of ADA1 inhibitors.
- 產品特點
- ? Rapid, and convenient ? The kit screens potential human Adenosine Deaminase Inhibitors
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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