- 中文名稱
磷酸化p38 MAPK（Thr1+Tyr122）易位測定試劑盒（基于細胞）
- 英文名字
- Phospho-p38 MAPK (Thr1??+Tyr1?2) Translocation Assay Kit (Cell-Based)
- 供應商
- Biovision
- 產品貨號
- K965-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate numerous physiological and pathophysiological cell responses. p38 MAPKs belong to a class that plays an important role during inflammatory processes, and their expression is upregulated by inflammatory and stress stimuli (cytokines, ultraviolet irradiation, osmotic and heat shock). p38 MAPKs are also involved in autophagy, apoptosis, cell differentiation, and are implicated in the regulation of inflammatory mediators levels such as tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). Accumulating evidence suggests that p38 MAPKs play an important role in arthritis, and inflammation of the liver, kidney, brain, and lung. Diseases induced by chronic inflammation, including gastritis, colitis, dermatitis, rheumatoid arthritis, pulmonary diseases and type II diabetes affect millions of people every year. Therefore, p38 is an important target in better understanding of inflammation and development of novel treatments. p38 MAPK is activated following phosphorylation at Thr180/Tyr182 by upstream MKK6 and MKK3 kinases. While in quiescent cells p38 localizes to both nucleus and cytosol, stress induced conformational changes within the active site result in selective translocation of activated-p38 into the nucleus. Thus, the selective nuclear accumulation of p38 could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets. BioVision’s Phospho-p38 MAPK (Thr180+Tyr182) Translocation Assay Kit (Cell-Based) provides a valuable tool to detect the nuclear translocation of activated p38 in fixed mammalian cells.
- 產品特點
- Detection of nuclear translocation of phosphorylated-p38 in mammalian cells
Screening effectors of p38 MAPK signaling pathway
Detection of cellular stress, DNA damage, heat shock, and pro-inflammatory stimuli
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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