- 中文名稱
p53核轉運分析試劑盒（基于細胞）
- 英文名字
- p53 Nuclear Translocation Assay Kit (Cell-Based)
- 供應商
- Biovision
- 產品貨號
- K961-50
- 產品報價
- ￥詢價/50assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- p53 is a tumor suppressor gene which encodes a transcription factor that controls cell’s destiny. This gene gets activated when cells are exposed to increased cellular stress, or DNA damage. The levels of p53 are elevated when post-translational modifications occur, which block its sequestration and/or ubiquitination by its destabilizer, Mouse Double Minute 2 Homolog (MDM2) which in turn is a transcriptional target of p53. Due to the three putative nuclear localization signals (NLSs) on its C-terminus, some of the activated p53 protein translocates into the nucleus and activate genes that induce cell cycle arrest, senescence, or apoptosis. The p53 gene is frequently mutated in cancer cells, and about 50% of cancers show p53 mutations, resulting in loss of its functions. The loss of p53 functionality can lead to dysregulation of many biological processes in cells, such as metabolic pathways, cellular homeostasis, cell movement, apoptosis, etc. BioVision’s p53 Nuclear Translocation Assay Kit (Cell-Based) provides an easy and complete assay kit to visualize the activation and nuclear translocation of p53 in human cells. This assay kit uses BioVision’s specific and sensitive human p53 antibody and a p53 secondary antibody to visualize the localization of p53 in fixed common human cells along with DAPI, a fluorescent stain, for nuclear staining. The kit includes Nutlin-3, a potent selective inhibitor that disrupts the protein-protein interaction between p53 and MDM2. Nutlin-3 serves as a control to induce p53 translocation from the cytoplasm to the nucleus
- 產品特點
- ? Simple procedure to visualize p53 nuclear translocation in ~ 3 hours
? Fast and contains Nutlin-3 that serves as a control to induce p53 translocation from the cytoplasm to the nucleus.
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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