p53轉錄因子活性測定試劑盒-p53 Transcription Factor Activity Assay Kit代理/參數/廠家-細胞分析試劑盒-艾美捷科技有限公司

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產品描述: The tumor suppressor protein p53 is one of the key players in cancer biology. DNA damage and oxidative stress signals lead to p53 posttranslational modifications and stabilization by binding to its consensus sequence, the p53 response element. Stabilized p53 can interact with other transcriptional regulators for the induction of p53-responsive targets involved in cell cycle progression, cell senescence, or apoptotic cell death. Because the expression and activity of p53 are frequently altered in human cancers, p53 becomes an important drug target as well as a biomarker in carcinogenesis. BioVision’s p53 Transcription Factor Activity Assay Kit is a non-radioactive assay for the quantitative measurement of specific transcription factor DNA binding activity?of active p53. A biotin-labeled p53 response element DNA binds specifically to active p53 in nuclear extract and forms a complex. The amount of complex is detected by the p53 specific monoclonal antibody using BioVision’s High-Sensitivity Streptavidin Plate. A HRP-conjugated secondary antibody provides a sensitive colorimetric readout at 450 nm using TMB as substrate.

產品特點: ? Easy, convenient and time-saving method to assay for human p53 ? The minimum detectable dose of p53 is typically less than 2 μg per sample ? This ELISA kit shows no cross-reactivity with the following cytokines tested: human Angiogenin, BDNF,BLC, ENA-78, FGF-4, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-11, IL-12 p70, IL-12 p40, IL-13, IL-15, IL-309, IP-10, G-CSF,GM-CSF, IFN-γ, Leptin (OB), MCP-1, MDC, MIP-1α, MIP-1 β, MIP-1δ, MMP-1, -2, -3, -10, PARC, RANTES, SCF, TARC, TGF-β, TIMP-1, TIMP-2, TNF-α, TNF-β, TPO, VEGF.

其他: BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.