- 中文名稱
【干冰】NFKB ANTIBODY SAMPLER KIT - K711
- 英文名字
- 【干冰】NFKB ANTIBODY SAMPLER KIT - K711
- 供應商
- Rockland
- 產品貨號
- K711
- 產品報價
- ￥詢價/1Kit
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- NFKB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
IKB-alpha inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKBA becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Anti-NFkB and Anti-IKBa Antibodies are ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction and Immunology research.
- 產品描述
- Each kit contains one unit of the following products:
Anti-NFKB p50 (NFKB1) (RABBIT) Antibody (100 μL)
Anti-NFKB p65 (Rel A) (RABBIT) Antibody (100 μL)
Anti-NFKB cRel (RABBIT) Antibody (100 μL)
Anti-IKBα C-terminal (RABBIT) Antibody (100 μL)
Anti-RABBIT IgG (H&L) (GOAT) Peroxidase Conjugated Antibody (100 μg)
CONTROL PEPTIDE for Anti-NFKB p50 (NFKB1) (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-NFKB p65 (Rel A) (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-NFKB cRel (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-IKBα C-terminal (RABBIT) Antibody ( (50 μg)
- 產品特點
- 該【干冰】NFKB ANTIBODY SAMPLER KIT - K711的詳細信息查看Rockland提供的產品說明書。
- 保存建議
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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