- 中文名稱
UCH-L3去泛素酶抑制劑篩選試劑盒
- 英文名字
- UCH-L3 Deubiquitinase Inhibitor Screening Kit
- 供應商
- Biovision
- 產品貨號
- K471-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- Diseases such as cancer and Alzehimer’s are often the result of dysregulation of proteostasis. Protein levels in the cell are regulated by both synthesis and degradation, with some proteins being marked for either localization or proteasomal degradation through the attachment of ubiquitin, a small, 76-amino acid protein. This attachment, termed ‘ubiquitination,’ or ‘ubiquitylation’ can be reversed by enzymes known as deubiquitinases (DUBs). The human proteome includes as many as four hundred DUBs, and thus these enzymes offer more specific targets for altering cellular equilibrium. UCH-L3, a DUB, is a cysteine protease that has been implicated in prostate cancer, although its regulation and downstream targets are largely unknown. It has been found that UCH-L3 is a novel regulator of epithelial-to-mesenchymal transition in cancer cell metastasis, making it an attractive drug target. Unfortunately, specific inhibitors for this and other DUBs are not readily available. Such compounds would also be a necessity for further illuminating and understanding downstream signaling. BioVision’s UCH-L3 Inhibitor Screening Kit utilizes the ability of active human UCH-L3 deubiquitinase to cleave a synthetic DUB substrate to release a fluorophore, which can be easily quantified (Ex/Em = 360/460 nm) using a fluorescence microplate reader. This inhibitor screening kit thus allows rapid and reliable determination of the inhibitory effects of various compounds on UCH-L3 deubiquitinase and could be used to screen for novel inhibitors. A nonspecific DUB inhibitor is included in this kit to allow the user to validate the experimental setup
- 產品特點
- ? Simple and reliable test to screen UCH-L3 inhibitors/activators
? High-throughput compatible
? Includes Inhibitor Control
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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