- 中文名稱
LDL攝取測定試劑盒（基于細胞）
- 英文名字
- LDL Uptake Assay Kit (Cell-Based)
- 供應商
- Biovision
- 產品貨號
- K436-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- Low-density lipoprotein (LDL) is a large spherical macromolecule that serves as a ‘shuttle’ to transport hydrophobic molecules (lipids and cholesterol) throughout the body via the aqueous environment of the bloodstream. An LDL particle consists of a hydrophobic core of cholesterol esters (with long-chain fatty acids linked to the hydroxyl group) and triglycerides surrounded by an amphipathic shell containing the 510 kDa protein Apolipoprotein B-100, various phospholipids and non-esterified cholesterol molecules. LDL is taken up by cells such as hepatocytes, macrophages, and endothelial cells by specific receptor-mediated endocytosis. High levels of LDL have been associated with arterial inflammation, which leads to cardiovascular diseases (CVD) like atherosclerosis, ischemic stroke and myocardial infarction. LDL particles can migrate through inflamed vascular endothelial tight junctions, where they become oxidized and attract circulating monocytes. Monocytes differentiate into activated macrophages, which further accumulate LDL and become foam cells, leading to arterial wall thickening/scaring and formation of fibrous fatty plaques. Current CVD preventative therapies include decreasing LDL with statins, which prevent endogenous cholesterol biosynthesis by inhibiting HMG-CoA reductase. However, drugs that inhibit LDL uptake by macrophages or enhance LDL clearance by increasing hepatic LDL reuptake are also being investigated. BioVision’s LDL Uptake Assay Kit enables measurement of receptor-mediated LDL uptake by various cell types. The kit contains fluorescent human LDL, which is covalently-labeled with a bright, highly photostable fluorophore that can be detected when taken up by cells (Ex/Em = 488/523 nm). Unlabeled human LDL is included in the kit for validation of specific labeled LDL uptake. The kit contains a complete set of reagents sufficient for performing 100 reactions and a 96-well polylysine-coated black cell culture plate with a thin, microscopy-grade clear bottom.
- 產品特點
- Measure LDL uptake in different cell types,Non-Radioactive,Contains fluorescent human LDL, which is covalently-labeled with a bright, highly photostable fluorophore,Screen, study or characterize stimulators or inhibitors of LDL uptake
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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