- 中文名稱
β-分泌酶（BACE1）活性測定試劑盒（熒光）
- 英文名字
- β-Secretase (BACE1) Activity Assay Kit (Fluorometric)
- 供應商
- Biovision
- 產品貨號
- K388-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- β-Secretase (EC 3.4.23.46), also called BACE1 (β-site of APP cleaving enzyme) or memapsin-2 (membrane-associated aspartic protease), is an aspartic-acid protease. Along with γ-secretase, BACE1 cleaves the APP (Membrane-anchored amyloid precursor protein) and generates soluble amyloid-β (Aβ). Accumulation of Aβ is the key event for pathogenesis of Alzheimer's disease, thus monitoring and targeting BACE1 activity are important for the study and development of therapeutic strategies that could alleviate/cure Alzheimer’s disease. Recent studies have shown that inhibiting BACE1 activity with synthetic compounds helped to slow or arrest Alzheimer’s disease symptoms. BioVision’s BACE1 Assay Kit II provides a fast and easy method for measuring BACE1 activity in a variety of samples. In this kit, a secretase-specific peptide is conjugated with two reporter molecules, EDANS and DABCYL. In the uncleaved form, the fluorescent emissions from EDANS are quenched by the physical proximity of the DABCYL moiety. Cleavage of the peptide by BACE1 separates EDANS and DABCYL groups allowing for the release of a strong fluorescent signal (Ex/Em= 345/500 nm). The level of secretase activity in samples is proportional to the level of fluorescence intensity. The assay is simple, sensitive, high–throughput adaptable and can detect BACE1 activity as low as 0.2 μU per sample
- 產品特點
- ? Simple procedure; takes ~ 1 hour
? Fast and convenient
? The assay is sensitive, stable and high-throughput adaptable.
? EDANS standard included
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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