- 中文名稱
c-Src激酶抑制劑篩選試劑盒
- 英文名字
- c-Src Kinase Inhibitor Screening Kit
- 供應商
- Biovision
- 產品貨號
- K2015-100
- 產品報價
- ￥詢價/100assays
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- 待更新
- 產品描述
- Cellular Src Kinase (c-Src, EC 2.7.10.2) is a non-receptor tyrosine kinase that regulates a wide array of cellular signal transduction pathways by phosphorylation of specific tyrosine residues in other tyrosine kinases. Src kinase family members interact with many proteins such as receptor tyrosine kinases, GPCRs, ion channels, steroid receptors, transcription activators, solute transporters and transmembrane adhesion receptors. c-Src was the first “proto-oncogene” to be identified. Over-expression of wild type c-Src or expression of a constitutively active mutant form is frequently found in a number of different cancers. Activation of c-Src enhances angiogenesis, proliferation and invasion pathways in tumors. The extent of this activation typically correlates with the malignant potential and patient survival. Despite the significant role of c-Src in oncogenesis, there are no known selective c-Src inhibitors. A number of clinically used tyrosine kinase inhibitors are capable of inhibiting c-Src. However, the currently available drugs are not selective and inhibit multiple kinases. Selective c-Src inhibitors may be more efficacious and can exhibit fewer side effects than the promiscuous multi-kinase inhibitors. BioVision’s c-Src Kinase Inhibitor Screening Kit enables rapid screening of test compounds for modulation of c-Src activity. The assay uses a c-Src-specific polypeptide substrate and a high concentration of the ultra-pure ATP that closely reflects the physiological ATP levels. ADP formation during the kinase reaction is measured. The strong and stable fluorescence signal (Ex/Em = 535/587 nm) generated during the reaction is directly proportional to the amount of ADP generated. This ensures a high signal-to-background ratio and a little interference due to short wavelength fluorescence by test compounds. The assay is simple, highly sensitive and is high-throughput adaptable. The kit contains a complete set of reagents sufficient for performing 100 reactions in a 96-well plate format.
- 產品特點
- Simple, Rapid screening of test compounds for modulation of c-Src activity, High-throughput adaptable, Highly sensitive
- 保存建議
- -80
- 其他
- BioVision的公司總部在美麗的舊金山灣地區，它是全球生命科學公司的領導者.BioVision在開發和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學研究工具而不斷擴大產品及服務質量.
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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