IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Fac-IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Factor, CXCL8)代理/參數/廠家-細胞分析試劑盒-艾美捷科技有限公司

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中文名稱: IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Fac

英文名字: IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Factor, CXCL8)

供應商: USBiological

產品貨號: I8430-01M

產品報價: ￥1/5x96Tests

產品說明書: 點擊查看

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產品描述: Intended Use:For the development of enzyme-linked immunospot (ELISpot) assays for the quantitation of single cells releasing human IL-8. For laboratory research use only. Not for use in diagnostic procedures.Background:Interleukin-8 (IL-8), also known as neutrophil attractant/activating protein (NAP-1), monocyte-derived neutrophil-activating peptide (MONAP), monocyte-derived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF) and leukocyte adhesion inhibitor (LAI), is a member of the chemokine superfamily which selectively chemoattract and activate specific leukocyte subpopulations (1,2). All of these cytokines have four conserved cysteines and two distinguishable subfamilies. These two subfamilies are dependent on the position of the first two cysteines, which are either separated by on amino acid (C-X-C proteins) or are adjacent (CC-protein) to each other. The members of the two subfamilies differ in their target cell selectivity as well as the chromosomal location of their genes (chromosome 4 for the C-X-C proteins and chromosome 17 for the C-C proteins). IL-8 belongs to the C- X-C subfamily along with platelet factor 4 (PF4), platelet basic protein (PBP), connective-tissue-activating peptide III (CTAPIII), b-thromboglobulin, neutrophil-activating peptide-2 (NAP-2), ENA-78 (3), three closely related MGSA/CRO gene products (GRO-a, GRO-b, GRO-g), and g-interferon-inducible protein (g-IP-10)(4). The members of the C-C chemokines are mainly chemotactic for monocytes whereas the C-X-C chemokines except for IP10 and PF4, chemoattract and activate neutrophils. In addition to the effect on neutrophils, IL-8 has been reported to be a less potent chemoattractant for T lymphocytes (5).IL-8 is produced by many cells in response to inflammatory stimuli such as IL-1b or TNF-a and to various types of mitogen, lectins, crystals, viruses, and phorbol esters (PMA). Many cell types that produce IL-8 in response to these stimuli can include: monocytes/ macrophages, T lymphocytes, neutrophils, fibroblasts, keratinocytes, hepacytes, chondrocytes, endothelial cells, glioblatoma cells , and mesothelial cells (6).The IL-8 predominant form secreted by stimulated monocytes has 72 residues (MW=85), whereas the predominant form secreted by IL-1 stimulated endothelial cells has 77 residues (MW=22). These variants have similar biological activities, although the 72-residue form of IL-8 appears to be 2 to 10 fold more potent than the 77-residue form depending on the type of assay used (7).Various non-infectious human diseases are known to be associated with neutrophilia and/or neutrophil infiltration into organs. Examples of some of these human diseases include rheumatoid arthritis, gouty arthritis, psoriasis, glomerulonephritis, adult respiratory distress syndrome, immune vasculitis, inflammatory bowel disease, ischemia-reperfusion syndrome (including myocardial infarction and multiple organ failure), chorioretinitis, cystic fibrosis, septic shock, acute meningococcal infections, alcoholic hepatitis and mediterranean fever (8). The presence of IL-8 has been positively identified in gouty arthritis, psoriatic scale, plasma from adult respiratory syndrome caused by sepsis, and serum from nephrotic syndrome as well as in the joint fluids from rheumatoid arthritis. The peripheral blood mononuclear cells (PBMC) obtained from patients undergoing an asthmatic attack have been shown to spontaneously produce in vitro IL-8-like molecules. The production of IL-8 triggers many other activities that contribute to these human diseases; however, IL-8 is not known to trigger systemic inflammatory reactions such as fever, acute phase protein induction.Kit Compnents:Concentrated Human IL-8 Capture Antibody: 1x1 vialConcentrated Human IL-8 Detection Antibody: 1x1 vialConcentrated Streptavidin (AP): 1x1 vialStorage and Stability:Store at -20°C. Stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

產品特點: 針對IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Factor, CXCL8)該產品的特點優勢，歡迎查閱官網提供的產品說明書。

保存建議: 建議收到IL8, Human, BioAssay ELISpot Kit, Development Set Development Set (Interleukin-8, IL-8, C-X-C Motif Chemokine 8, Emoctakin, MDNCF, MONAP, Neutrophil-activating Protein 1, NAP-1, T-cell Chemotactic Factor, CXCL8)產品后將其置于-20°C保存。

其他: Usbiological公司是美國著名的抗體和生化試劑供應商，生產世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細胞術等多種檢測方法。Usbiological公司現已擁有超過50,19234種抗體、抗原和生化產品，為科研用戶提供了諸多超值選擇。