Cyclosporin A is a noncytotoxic， natural， 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function， which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells， does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless， Cyclosporin A -induced nephrotoxicity remains an important clinical problem， and oxidative stress has been implicated as a potential responsible mechanism.
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來源宿主
Beauveria Nlyea.中提取純化
溶解建議
Sterile Filtered White lyophilized （freeze-dried） powder. The Cyclosporin-A was lyophilized from a concentrated （1mg/ml） solution with no additives. It is recommended to reconstitute the lyophilized Cyclosporin A in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建議
Lyophilized Cyclosporin A although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Cyclosporin A should be stored at 4℃ between 2-7 days and for future use below -18℃.
Please prevent freeze-thaw cycles.
