Group IB secretory phospholipase A2（sPLA2-IB) mediates cell proliferation， cell migration， hormone release and eicosanoid production via its receptor in peripheral tissues. In the CNS， high-affinity binding sites of sPLA2-IB have been documented. sPLA2-IB induced neuronal cell death in a concentrationdependent manner depending on PGD2 metabolites， especially Delta12-PGJ2 that might mediate sPLA2-IB-induced apoptosis. The secretory PLA2（sPLA2) family， in which 10 isozymes have been identified， consists of lowmolecular weight， Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes， such as modification of eicosanoid generation， inflammation， and host defense.
