PRMT1 Methylates（mono & asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain（may methylate HNRNPA1 and histones). Methylates SUPT5H.
The PRMT1 protein functions as a histone methyltransferase specific for H4.
PRMT1 is an essential factor in oncogenesis and is a potential novel therapeutic target in cancer.
PRMT1-mediated methylation serves as a positive modulator of IR/IRS-1/PI3K pathway and glucose uptake in skeletal muscle cells.
CAF1 is a new regulator of PRMT1-dependent arginine methylation.
PRMT1 arginine-methylates MRE11 therefore it regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.
PRMT1 plays a post-translationally part in regulating the transcriptional activity.
PRMT1is found predominantly in the cytoplasma though a fraction of PRMT1 is located in the nucleus.
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大腸桿菌中重組表達
溶解建議
提供的小鼠蛋白質精氨酸甲基轉移酶-1（mPRMT1）產品為過濾滅菌的無色溶液；其中小鼠蛋白質精氨酸甲基轉移酶-1（mPRMT1）產品溶解于40mM Tris pH 8.0， 100mM NaCl， 4mM MgCl2， 2mM DTT，40%甘油溶液中.
