93-O 17 S是一種用于產生脂質納米顆粒以遞送RNA肽和核苷酸的類胡蘿卜素。93- 017 S LNP能夠在小鼠中遞送Cre重組酶mRNA。此外，LNP能夠將Cre重組酶蛋白和Cas9：單向導RNA遞送到細胞中用于基因組編輯。93-O 17 S LNP用于在注射到小鼠B16 F10腫瘤中時遞送STING途徑激動劑2 - 3-環GMP-AMP（cGAMP），其具有作為原位癌癥疫苗的潛力。
產品描述
93-O17S is a lipidoid used for generating lipid nanoparticles to deliver RNA peptides and nucleotides. 93-O17S LNPs were able to deliver Cre recombinase mRNA in mice. In addition LNPs were able to deliver the Cre recombinase protein and Cas9:single-guide RNA into cells for genome editing. 93-O17S LNPs were used to deliver the STING pathway agonist 2a€23a€2-Cyclic GMP-AMP (cGAMP) when injected into B16F10 tumors in mice which has potential as an in situ cancer vaccine.
