AA 3-DLin是一種可電離的脂質，用于產生用于RNA遞送的脂質納米顆粒（LNP）。與用其它可電離脂質配制的LNP不同，AA 3-DLin LNP在較高比例的磷脂和較低膽固醇（40：40：25：0.5 AA 3-DLin/DOPE/膽固醇/DMG-PEG）下表現最佳。含有AA 3-DLin的LNP能夠將全長SARS-COV 2刺突蛋白mRNA遞送至BALB/c小鼠并產生強烈的免疫應答。
產品描述
AA3-DLin is an ionizable lipid used in generating lipid nanoparticles (LNPs) for RNA delivery. Unlike LNPs formulated with other ionizable lipids AA3-DLin LNPs performed best with higher proportions of phospholipid and lower cholesterol (40:40:25:0.5 AA3-DLin/DOPE/cholesterol/DMG-PEG). AA3-DLin containing LNPs were able to deliver full-length SARS-COV2 spike protein mRNA to BALB/c mice and generate a strong immune response.
