硝基油酸（OA-NO2）是在炎癥（硝化應激）期間由過量的一氧化氮硝化油酸而形成的。OA-NO2是一種有效的信號分子，可以激活多種受體，包括TRPA 1陽離子通道和PPAR 3。9（10）-硝基油酸是9-硝基和10-硝基異構體的混合物，它們在體內以等量形成。P.S. Baker et al "Fatty Acid Transduction of Nitric Oxide signaling“ Journal of Biological Chemistry 2005 280 42464-42475;2. F. J. Schopfer et al“共價過氧化物酶體分解激活受體通過硝基脂肪酸的加合”Journal of Biological Chemistry 2010 285 12321-12333.?
產品描述
Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPAR?3. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.References1. P.S. Baker et al a€?Fatty Acid Transduction of Nitric Oxide signalinga€? Journal of Biological Chemistry 2005 280 42464-42475;2. F.J. Schopfer et al a€?Covalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acida€? Journal of Biological Chemistry 2010 285 12321-12333.
