FTY 720 P是新型免疫抑制藥物芬戈莫德（FTY 720）的生物活性形式。FTY 720通過鞘氨醇激酶轉化為FTY 720 P，（S）-異構體作為四種S1 P受體（S1 P1 3 4 5）的激動劑，IC 50分別為2.1、5.9、23和2.2 nM。R異構體以低5-10倍的親和力結合。FTY 720 P通過細胞外信號調節激酶（ERK）信號通路促進新生大鼠少突膠質細胞存活、調節少突膠質細胞祖細胞分化、促進星形膠質細胞遷移。最近發表的結果表明，FTY 720 P參與淋巴脈絡叢腦膜炎病毒（LCMV）克隆13引起的持續性感染的完全病毒清除。出版物由Bioz提供技術支持查看Bioz 1的更多詳情。布基河 等（2010年）。“血漿凝溶膠蛋白調節細胞對1-磷酸鞘氨醇的反應?！懊绹韺W雜志細胞生理學299（6）：C1516-1523.2。古Y。 等（2011年）。“上皮細胞擠出需要鞘氨醇-1-磷酸受體2途徑?！都毎飳W雜志》193（4）：667-676.3。特爾科夫灣 等（2012年）。芬戈莫德-一種鞘氨醇樣分子抑制星形膠質細胞中囊泡的流動性和分泌。“Glia 60（9）：1406.4。薩穆韋爾灣等（2015）. AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.“PLoS ONE 10（10）：e0141781.5.巴以法蓮E. 等（2019）。CD 62 L是循環先天類淋巴細胞前體的功能和表型標志物?！睹庖邔W雜志》202（1）：171-182。
產品描述
FTY720P is the bioactive form of the novel immunosuppressive drug fingolimod (FTY720). FTY720 is converted to FTY720P by sphingosine kinase and the (S)-isomer acts as an agonist to four S1P receptors (S1P1 3 4 5) with IC50s of 2.1 5.9 23 and 2.2 nM respectively. The R isomer binds with 5-10 fold lower affinity. FTY720P improves the survival of neonatal rat oligodendrocytes regulates oligodendrocyte progenitor cells differentiation promotes astrocyte migration via extracellular signal-regulated kinase (ERK) signaling. Recently published results indicate involvement of FTY720P in complete viral clearance of persistent infection caused by clone 13 of lymphotic choriomeningitis virus (LCMV).Publications Powered by Bioz See more details on Bioz1. Bucki R. et al. (2010). "Plasma gelsolin modulates cellular response to sphingosine 1-phosphate." Am J Physiol Cell Physiol 299(6): C1516-1523.2. Gu Y. et al. (2011). "Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway." The Journal of Cell Biology 193(4): 667-676.3. Trkov S. et al. (2012). "Fingolimoda€”A sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes." Glia 60(9): 1406.4. Samuvel D. J. et al. (2015). "AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis." PLoS ONE 10(10): e0141781.5. Bar-Ephraim Y. E. et al. (2019). "CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors." The Journal of Immunology 202(1): 171-182.
