透明質酸酶（HA se）是降解透明質酸（HA）的一組酶，透明質酸是由N-乙酰葡糖胺和D-葡糖醛酸的重復二糖組成的線性多糖。HA參與許多生物學過程，包括結構支持、細胞遷移和組織更新。透明質酸酶參與多種病理過程，例如細菌發病機制、毒素/毒液的擴散和癌癥進展，使得透明質酸酶成為潛在的藥理學靶標。6-O-棕櫚酰-L-抗壞血酸（Vcpal）是細菌和哺乳動物透明質酸酶的微摩爾HAse抑制劑，并且其對無乳鏈球菌酶具有特別選擇性。L-抗壞血酸6-十六烷酸酯是一種有效的透明質酸酶抑制劑：酶抑制劑復合物的X射線結構和分子建模。J. Biol. Chem. 2004 279 45990-45997。2)斯皮肯里特河等人，Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorg.醫學化學快報 2006 16 5313-5316。
產品描述
Hyaluronidases (HAse) are a group of enzymes that degrade Hyaluronan (HA) a linear polysaccharide comprised of a repeating disaccharide of N-acetylglucosamine and D-glucuronic acid. HA is involved in many biological processes including structural support cell migration and tissue turnover. Hyaluronidases are involved in several pathological processes such as bacterial pathogenesis the spreading of toxins/venoms and cancer progression making hyaluronidases a potential pharmacological target. 6-O-Palmitoyl-L-ascorbic acid (Vcpal) is a micromolar HAse inhibitor of both bacterial and mammalian hyaluronidases and it is particularly selective for the Streptococcus agalactiae enzyme.References1) A. Botzki et al. L-Ascorbic Acid 6-Hexadecanoate a Potent Hyaluronidase Inhibitor: X-ray structure and molecular modeling of enzyme-inhibitor complexes. J. Biol. Chem. 2004 279 45990-45997. 2) Spickenreither M. et al. Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorg. Med. Chem. Lett. 2006 16 5313-5316.
