PS48通過僅與PIF結合口袋而不是ATP結合位點結合來激活磷酸肌醇依賴性蛋白激酶1（PDK 1）。Stroba等人，“5-Diphenyleneorbenzo-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK 1：Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds”，J. Med. Chem 2009 52（15）4683-46932）L.D. Spate et al.“PS48可以取代豬胚胎培養基中的牛血清白蛋白，通過磷酸化AKT改善體外胚胎發育”《分子生殖發展》2015 DOI：10.1002/mrd.22474。
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PS48 activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to PIF-binding pocket rather than the ATP binding site.References1) A. Stroba et al. a€?3 5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure-Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compoundsa€? J. Med. Chem 2009 52 (15) 4683-46932) L.D. Spate et al. a€?PS48 can replace bovine serum albumin in pig embryo culture medium and improve in vitro embryo development by phosphorylating AKTa€? Molecular Reproduction & Development 2015 DOI: 10.1002/mrd.22474.
