AS 1949490是一種有效的選擇性SHIP 2抑制劑，對人的IC 50為0.62 μ M，對SHIP 1影響較小或對其他類型的細胞內磷酸酶（如PTEN synaptojanin和myotubularin）無影響。該化合物還能激活肝臟中的細胞內胰島素信號通路，并顯示出促胰島素生成調節和抗糖尿病作用。蘇瓦河Yamanoto等人，“Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase SHIP 2”British Journal of Pharmacology 2009 158 879-88.
產品描述
AS1949490 is a potent selective SHIP2 inhibitor with IC50 of 0.62 uM for human which shows less effect on SHIP1 or no effects on some other types of intracellular phosphatases (such as PTEN synaptojanin and myotubularin). This compound also activates intracellular insulin signaling pathways in the liver and displays gluconeogensis regulation and antidiabetic effects.References Powered by Bioz See more details on BiozA. Suwa T. Yamanoto et al. "Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase SHIP2" British Journal of Pharmacology 2009 158 879-88.
