IC 87114是PI 3-激酶β ′的特異性抑制劑（IC 50 = 0.5 μ M），選擇性是其他亞型的60倍（IC 50：β ′ = 100 μ M β ′ = 75 μ M β ′ = 29 μ M）。在10 μ M時，它不抑制其他蛋白激酶（p38 MAPK CHK 1 cSrc PKB 1 ± CK 1 PKC 1 ± PKC 2 II）。PI 3-K δ在炎癥中具有重要作用，并且抑制已顯示損害中性粒細胞遷移。在小鼠哮喘模型中給予IC 87114可降低過敏性氣道炎癥。Publications Powered by Bioz See more details on Bioz
產品描述
IC87114 is a specific inhibitor of PI 3-kinase ?′ (IC50 = 0.5 ??M) with >60-fold selectivity over other isoforms (IC50: ?± = >100 ??M ?2 = 75 ??M ?3 = 29 ??M). It does not inhibit other protein kinases (p38MAPK CHK1 cSrc PKB?± CK1 PKC?± PKC?2II) at 10 uM. PI 3-K &delta has an important role in inflammation and inhibition has been shown to impair neutrophil migration. Administration of IC87114 in a mouse asthma model decreased allergic airway inflammation.Publications Powered by Bioz See more details on Bioz
