5-（2-二氟-苯并[1 3]間二氧雜環戊烯-5-基亞甲基）-噻唑烷-2-4-二酮（AS 604850）是PI 3-Ketamine 3的抑制劑，IC 50 = 250 nM。AS 604850對β 3-亞型具有選擇性（IC 50：PI 3-Keto 2 = 4.5 μ M PI 3-Keto 2 PI 3-Keto 2 20 μ M），在1 μ M濃度下對多種蛋白激酶無明顯活性。參考資料由Bioz提供技術支持更多詳情請參閱Bioz 1）M。Camps等人，“Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis”Nature Medicine 2005 11 936-943.
產品描述
5-(2 2-Difluoro-benzo[1 3]dioxol-5-ylmethylene)-thiazolidine-2 4-dione (AS604850) is an inhibitor of PI 3-K?3 with an IC50 = 250 nM. AS604850 is selective for the ?3-isoform (IC50: PI 3-K?± = 4.5 ??M PI 3-K?2 PI 3-K?′ > 20 ??M) and shows no notable activity against a wide array of protein kinases at 1 ??M.References Powered by Bioz See more details on Bioz1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine 2005 11 936-943.
