白藜蘆醇是一種IA類PI3K抑制劑，可激活SIRT1并對人乳腺上皮細胞顯示抗增殖作用。白藜蘆醇通過線粒體膜去極化和caspase-9激活誘導細胞凋亡。此外，白藜蘆醇抑制核糖核苷酸還原酶和DNA合成，環氧合酶-1 PKD和類花生酸合成。參考文獻1）S Fr?jd?et al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511（2007）2）K.T. Howitz等人，Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifetime. 3）O.P.Mgbonyebi等人，合成白藜蘆醇對人乳腺上皮細胞的抗增殖作用。國際腫瘤學雜志12 865（1998）3）J.Dorrie等，Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res.614731（2001）4）M.白藜蘆醇是核糖核苷酸還原酶的顯著抑制劑。FEBS Lett. 421 277（1998）白藜蘆醇的癌癥化學預防活性，一種來自葡萄的天然產物。6）J.R.白藜蘆醇對佛波酯反應性蛋白激酶自磷酸化的影響：抑制蛋白激酶D但不抑制蛋白激酶C同工酶自磷酸化。Biochem. Pharmacol. 60 1355（2000年）
產品描述
Resveratrol is a class IA PI3K inhibitor activates SIRT1 and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition Resveratrol inhibits ribonucleotide reductase and DNA synthesis cyclooxygenase-1 PKD and eicosanoid synthesis.References1) S Fr??jd?? et al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511 (2007)2) K.T. Howitz et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191 (2003)3) O.P. Mgbonyebi et al. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12 865 (1998)3) J. Dorrie et al. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61 4731 (2001)4) M. Fontecave et al. Resveratrol a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 421 277 (1998)5) M. Jang et al. Cancer chemopreventive activity of resveratrol a natural product derived from grapes. Science 275 218-220 (1997)6) J.R. Stewart et al. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem. Pharmacol. 60 1355 (2000)
