IL-32 is part of the cytokine family and contains a tyrosine sulfation site，3 potential N-myristoylation sites，multiple putative phosphorylation sites，and an RGD cell-attachment sequence. IL-32 expression is elevated after the activation of T-cells by mitogens or the activation of NK cells by IL-2. IL-32 induces the production of TNF-a from macrophage cells. IL-32 pro-inflammatory pathway is activated in response to influenza A virus infection. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
Induction of TNF，IL-1beta，and IL-6 by IL-32 is intervened by p38-MAPK. IL-32 induced monocyte-to-macrophage differentiation is mediated through nonapoptotic，caspase-3-dependent mechanisms. IL32 plays an important role in the pathogenesis of rheumatoid arthritis. IL-32 is involved in activation-induced cell death in T cells，through its intracellular actions. IL-32 is a cell-associated proinflammatory cytokine，which is particularly stimulated by mycobacteria through a caspase-1- and IL-18-dependent production of interferon gamma.
IL-32 is associated with TNF-a，IL-1beta，and IL-18. IL32 is involved in human rheumatoid arthritis and is a novel target in autoimmune diseases.
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來源宿主
大腸桿菌中重組表達
溶解建議
提供的人白介素-32a，His標簽（IL 32A His Tag）產品為過濾滅菌的無色溶液；其中人白介素-32a，His標簽（IL 32A His Tag）產品溶解于20mM Tris-HCl（pH 8），1mM DTT和10%甘油溶液中.
保存建議
人白介素-32a，His標簽（IL 32A His Tag）溶液可以在4℃冷藏保存2-4周時間；如果想延長保存時間，建議分裝（加載體蛋白如0.1% HSA或 BSA）后置于-20℃凍存.請避免反復凍融.
