MAL-dPEG? β-Glu(OH)-NH-m-dPEG? β-Glu-250 mg-MAL-dPEG??-Glu(OH)-NH-m-dPEG???-250 mg代理/參數/廠家-生化試劑-艾美捷科技有限公司

PRODUCT CENTER

生化試劑

產品中心

當前位置：首頁 > 產品中心 > 分子生化產品 > 生化試劑

中文名稱: MAL-dPEG? β-Glu(OH)-NH-m-dPEG? β-Glu-250 mg

英文名字: MAL-dPEG??-Glu(OH)-NH-m-dPEG???-250 mg

供應商: Click Chemistry Tools

產品貨號: CCT-QBD-11580-250

產品報價: ￥詢價/250mg

產品說明書: 點擊查看

購買方式: 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系。本公司所有產品僅供科研使用，不用于臨床診斷。

產品新聞

背景資料: MAL-dPEG?4-Glu(OH)-NH-m-dPEG?24，產品編號QBD-11580，是Vector Laboratories獨特的、獲得專利的模塊化、可設計的有效載荷遞送試劑之一，稱為Sidewinder?。Sidewinder?產品構建在離散PEG(dPEG?)主鏈上，用于抗體-藥物綴合物(ADC)和相關構建體。有效載荷(細胞毒素，染料，小分子)裝載到鏈的側臂上。遠端的甲氧基封端的dPEG?24間隔基保護有效載荷并改變性能。MAL-dPEG?4-Glu(OH)-NH-m-dPEG?24(產品編號QBD-11580)的馬來酰亞胺反應性基團通過硫醇-馬來酰亞胺反應(邁克爾加成反應)與生物分子上的游離硫醇反應以形成穩定的硫醚鍵。側臂是胺反應性羧酸。它可以直接與游離胺反應，使用碳二亞胺如EDC形成穩定的酰胺鍵。或者，羧酸可以用N-羥基琥珀酰亞胺(NHS酯)或2，3，5，6-四氟苯酚(TFP酯)官能化為活性酯，然后與游離胺反應。

產品描述: MAL-dPEG?4-Glu(OH)-NH-m-dPEG?24, product number QBD-11580, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder?. Sidewinder? products are built on a discrete PEG (dPEG?) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG?24 spacer protects payloads and modifies performance.nThe maleimide reactive group of MAL-dPEG?4-Glu(OH)-NH-m-dPEG?24, product number QBD-11580, reacts with free thiols on the biomolecule through the thiol-maleimide reaction (a Michael addition reaction) to form a stable thioether bond. The sidearm is an amine-reactive carboxylic acid. It can be reacted directly with free amines to form stable amide bonds using a carbodiimide like EDC. Alternatively, the carboxylic acid can be functionalized as the active ester with N-hydroxysuccinimide (NHS ester) or 2,3,5,6-tetrafluorophenol (TFP ester) and then reacted with free amines.nSidewinder? products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload (e.g., a cytotoxin) close to the antibody surface and protecting it with a SuperHydrophilic? dPEG? construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.nThe dPEG? linkers and spacers in the Sidewinder? construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG? products are high-purity compounds with reproducible purity profiles.nSidewinder? molecules are also fully designable. MAL-dPEG?4-Glu(OH)-NH-m-dPEG?24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the maleimide attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.

產品形式: 白色至琥珀色固體

保存建議

其他: Click Chemistry Tools（CCT）公司位于美國亞利桑那州斯科茨代爾（Scottsdale,AZ）。自公司成立以來，一致致力于不斷開發和擴展一系列連接產品。他們利用特別新的研究成果研發生產出新穎的交聯和標記試劑。產品被廣泛用于藥物研發、癌癥治療以及各類診斷技術等。此外，CCT還可以提供個性化的定制產品，已滿足不同用戶的需求。目前CCT的產品線主要包括：Azides（Biotin-Azides）試劑、Bis-sulfone交聯試劑、DBCO試劑、TCO試劑、Terminal Alkyne試劑、Tetrazine試劑、標記試劑盒以及分選用底物等。nFluoroprobes公司位于美國亞利桑那州斯科茨代爾(Scottsdale, AZ)，自成立以來，一直致力于不斷開發一系列的連接(linker)產品。利用特別新的研究成果研發生產出各類新穎的交聯和標記試劑。其產品被廣泛用于藥物研發與篩選、疾病治療方法和診斷技術等領域。此外，Fluoroprobes還可以根據客戶的個性化需求提供各類定制連接產品。代表產品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些標記試劑盒等。nQuanta Biodesign公司位于美國中部的俄亥俄州，成立于1997年。也是專注于生產研發各類標記產品的品牌之一。其研發的產品與dPEG技術相結合，生產出他們獨有的專利產品dPEG Building Blocks and Linkers，被廣泛用于細胞治療和分子診斷等研究領域。另外，還可為廣大科研工作者提供多種化學修飾試劑以及傳統Liner等。n目前上述三個品牌都已被被Vectorlabs收購并整合到Vectorlabs產品中