- 中文名稱
重組FGFR-1α（IIIc）-Fc，人
- 英文名字
- RecombinantFGFR-1α(IIIc)-Fc,Human
- 供應商
- Bioworld
- 產品貨號
- BK0354
- 產品報價
- ￥詢價/10ug
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Fibroblast Growth Factor Receptor-1 (FGFR-1) is a transmembrane tyrosine kinase receptor belonging to the FGFR family. FGFR family has 4 members, FGFR-1 to FGFR-4, and they all have similar structural characteristics with 3 extracellular immunoglobulin-like (Ig) domains. FGFRs bind to FGFs with the second and third Ig domains, and complex with heparin sulfate when binding. The binding to FGF induces the dimerziation of FGFR and the phosphorylations of the intracellular tyrosines. Furthermore, the phosphorylated FGFR activates downstream signaling pathways, including STAT/JAK, RAS/MAPK, and PI3 K/AKT. Particularly, the signaling of FGFR-1 is stronger than that of FGFR-2, and sustains longer than that of FGFR-4. FGFR-1 is involved in the breast cancer: the patients with the FGFR-1 amplification are more likely to develop distant metastases, and the amplification of FGFR-1 is significantly associated with a shorter overall survival. Recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) produced in Sf9 is a single glycosylated polypeptide chain containing 592 amino acids. A fully biologically active molecule, rhFGFR-1 alpha(IIIc)-Fc has a molecular mass of around 90 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
- 序列
- RPSP TLPEQAQPWG APVEVESFLV HPGDLLQLRC RLRDDVQSIN WLRDGVQLAE SNRTRITGEE VEVQDSVPAD SGLYACVTSS PSGSDTTYFS VNVSDALPSS EDDDDDDDSS SEEKETDNTK PNPVAPYWTS PEKMEKKLHA VPAAKTVKFK CPSSGTPNPT LRWLKNGKEF KPDHRIGGYK VRYATWSIIM DSVVPSDKGN YTCIVENEYG SINHTYQLDV VERSPHRPIL QAGLPANKTV ALGSNVEFMC KVYSDPQPHI QWLKHIEVNG SKIGPDNLPY VQILKTAGVN TTDKEMEVLH LRNVSFEDAG EYTCLAGNSI GLSHHSAWLT VLEALEERPA VMTSPLYLEG SGSGSGSPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK
- 來源宿主
- SF9 insect cells
- 溶解建議
- Reconstituted in ddH2O at 100 μg/mL.
- 保存建議
- Lyophilized recombinant human FGFR-1 alpha(IIIc)-Fc (rhFGFR-1 alpha(IIIc)-Fc) remains stable up to 6 months at -80
- 其他
- Bioworld是專一服務于生命科學研究的專業技術型企業，Bioworld品牌創立以來擁有10000多種常規產品現貨，現有8000多種現貨抗體，以及其他IVD原料，蛋白等現貨產品。在細胞信號通路、免疫學、蛋白組學上擁有顯著優勢，其抗體產品、生長因子、IVD原料等為生命科學科研工作者提供了極大的便利
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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