F-Actin 可視化試劑盒-F-Actin Visualization Kit代理/參數/廠家-細胞分析試劑盒-艾美捷科技有限公司

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產品特點: Conventional actins have a relative molecular mass of approximately 43 kDa. Monomeric actin (G-actin) can self-assemble (polymerize) into microfilaments (F-actin), the fundamental unit of the actin cytoskeleton. Actins are highly conserved within the eukaryotic kingdom and exist in higher eukaryotes as multigene families. Isoforms show distinct cellular and sub-cellular expression and localization. It has been demonstrated that different isoforms have subtly different biochemical properties in vitro which supports functional diversity within isotypes in vivo (1). The actin cytoskeleton is a highly dynamic structure, a property under the tight regulation of more than 150 actin binding proteins (ABPs) (2, 3). It is involved in a large number of cellular processes, including muscle contraction, lamellopodia extrusion, cell locomotion, cytokinesis, intracellular transport and cytoplasmic streaming (1). The morphology of the actin cytoskeleton changes rapidly in response to a wide variety of internal and external stimuli. For example, figure 1 shows that calpeptin stimulation of serum starved 3T3 cells results in a rapid accumulation of actin stress fibers. This reponse is due to the activation of the small GTPase RhoA (4). As a further example, many pathogenic bacteria and viruses harness the host actin cytoskeleton for their intracellular spread, resulting in characteristic actin comet tails (5).

其他: Cytoskeleton公司成立于1993年，專注于生物化學和細胞過程研究中的純化蛋白和便捷試劑盒開發與生產。公司提供藥物篩選、信號轉導、蛋白質轉錄后修飾（PTM）、細胞骨架研究相關的系列試劑盒和產品，尤其以細胞骨架相關研究見長，既能滿足于樣品較少的科學研究，也可以用于小規模篩選研究和高通量大規模篩選研究。此外，公司還提供微管蛋白，肌動蛋白，小G蛋白，GAPs，GEFs等現有產品的藥物篩選服務。