B型腦鈉肽 EIA試劑盒-BNP Fragment EIA Kit代理/參數/廠家-ELISA試劑盒-艾美捷科技有限公司

PRODUCT CENTER

ELISA試劑盒

產品中心

當前位置：首頁 > 產品中心 > 免疫學產品 > ELISA試劑盒

背景資料: The natriuretic peptides are members of a family of structurally similar but genetically distinct peptide hormones, consisting of atrial-, brain-, and C-type (ANP, BNP, and CNP, respectively). ANP and BNP preferentially bind to a membrane-bound guanylyl cyclase (GC) receptor called GC-A or NPR1, whereas CNP is the physiological ligand for GC-B (NPR2). The natriuretic peptides play an important role in the regulation of cardiovascular and renal homeostasis and in the regulation of fatty acid metabolism and body weight.

BNP is mainly expressed by ventricular myocardium in response to volume overload and increased filling pressure. BNP has a cleavable signal sequence. Mature BNP consists of 108 amino acids (proBNP or BNP-108), and undergoes cleavage resulting in physiologically active BNP-32 and additional C-terminal fragments (cf. http://www.uniprot.org/uniprot/P16860#PRO_0000001532), along with a physiologically inactive N-terminal peptide comprising amino acids 1-76 (NT-proBNP), which is further degraded proteolytically.

產品描述: Method Competitive enzyme immunoassay (EIA), HRP/TMB, 12×8-well detachable strips Sample type Serum, EDTA plasma, hepar?n plasma, citrate plasma Product volume 30 μl / well Assay time Overnight (18 – 25 h) / 20 min Sensitivity 171 pmol/l (=1449 pg/ml) Standard range 0 – 6,400 pmol/l (0 – 54,237 pg/ml) Conversion factor 1 pmol/l = 8.475 pg/ml (MW: 8.475 kDa) Specificity Endogenous and recombinant human NT-proBNP. Precision In-between-run (n=8): ≤ 7 % CV Within-run (n=3): ≤ 3 % CV Cross-reactivity The assay does not cross react with rat, mouse, dog, or cat samples.

其他: Biomedica Immunoassay(bmgrp)公司成立于1988年, 總部位于奧地利維也納，主要致力于研究、開發和生產基于ELISA方法用于臨床前研究相關標記物檢測的工具。迄今為止Biomedica Immunoassay公司在心血管檢測及骨代謝檢測領域開發了一系列特色ELISA檢測試劑盒，Biomedica Immunoassay的生產過程符合GMP/GLP指南，并符合ISO 9001:2015管理體系，有CE認證。Biomedica Immunoassay的產品根據FDA， EMEA和ICH指南進行驗證，并具有驗證報告。