- 中文名稱
大內皮素Elisa試劑盒
- 英文名字
- Big Endothelin-1 ELISA Kit
- 供應商
- Biomedica Immunoassays
- 產品貨號
- BI-20082H
- 產品報價
- ￥12x8tests
- 產品說明書
- 點擊查看
- 購買方式
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- 產品新聞
- 背景資料
- Big Endothelin-1 (BigET-1) is a peptide of 38 amino acids and is the precursor of Endothelin-1 (ET-1), consisting of amino acids 1-21 (http://www.uniprot.org/uniprot/P05305). ET-1 is a potent vasoconstrictor and is produced by vascular endothelial cells. Accordingly, it has a wide tissue distribution (http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.511899). The cleavage of BigET-1 by the Endothelin-converting enzyme (ECE) converts BigET-1 to Endothelin (ET) and to a C?terminal fragment.
The half-life of ET-1 (1-21) in plasma is less than one minute, which may preclude its use as a diagnostic marker, whereas clearance of the precursor peptide BigET-1 is much slower. As Big-Endothelin-1 is produced at amounts equimolar to ET-1 and has higher plasma stability, it is more suitable for diagnostics and monitoring of heart failure (Gergei et al., 2018). Hence, Big ET-1 has the same physiological role as ET-1 while being a more reliable marker.
- 產品描述
- Method
Sandwich ELISA, HRP/TMB, 12×8-well detachable strips
Sample type
Serum, EDTA plasma. citrate plasma, hepar?n plasma
Sample volume
50 μl / well
Assay time
4 h / 1 h / 30 min
Sensitivity
0.02 pmol/l (= 0.086 pg/ml)
Standard range
0 – 3 pmol/l (= 0 – 12.85 pg/ml)
Conversion factor
1 pmol/l = 4.283 pg/ml (MW: 4.283 kDa)
Precision
In-between-run (n=5): ≤ 5 % CV
Within-run (n=10): ≤ 4 % CV
Specificity
Endogenous and recombinant Big Endothelin-1 (Big ET-1 (1-38)).
Cross-reactivity
Human ET1/2/3 (1-21): <1%, human ET2 (1-37): <1%, human ET1/2 (1-38): <1%, human BigET1/2 (22-38) : <1%, human BigET2 (22-37) : <1%,
porcine BigET (1-39): 21%, rat BigET1 (1-39): 10%, Sarafotoxin: <1%
- 產品特點
- 保存建議
- +4°C
- 其他
- Biomedica Immunoassay(bmgrp)公司成立于1988年, 總部位于奧地利維也納，主要致力于研究、開發和生產基于ELISA方法用于臨床前研究相關標記物檢測的工具。迄今為止Biomedica Immunoassay公司在心血管檢測及骨代謝檢測領域開發了一系列特色ELISA檢測試劑盒，Biomedica Immunoassay的生產過程符合GMP/GLP指南，并符合ISO 9001:2015管理體系，有CE認證。Biomedica Immunoassay的產品根據FDA， EMEA和ICH指南進行驗證，并具有驗證報告。
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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