高遷移率族蛋白B1(high mobility group protein,HMGB1)是一種高度保守的核蛋白,廣泛分布于哺乳動物細胞.隨著其晚期促炎作用的發現,HMGB1成為近年來危重醫學研究的熱點之一.本文就其家族分類、基因和蛋白結構、細胞生物學效應方究進展進行綜述.
應用類型
ELISA, Western blot and immunohistochemistry?
免疫原
Anti-human HMGB1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMGB1 amino acids 1-215 purified from High Five (Trichoplusia ni) insect cells.