c-Myc is a multifunctional， nuclear phosphoprotein that plays a role in cell cycle progression， apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations， overexpression， rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors， leukemias and lymphomas， including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream， in-frame non-AUG （CUG） and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas， suggesting its importance in the normal function of this gene.
應用類型
Western Blot， Immunoprecipitation.
免疫原
Monoclonal antibodies are produced by immunizing mouse with synthetic peptide （EQKLISEEDL） coupled to KLH.
