- 中文名稱
PAPP-A / Stanniocalcin 2 復合物 ELISA
- 英文名字
- PAPP-A / Stanniocalcin 2 Complex ELISA
- 供應商
- Ansh Labs
- 產品貨號
- AL-166
- 產品報價
- ￥詢價/96wellmicrotiter
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role has remained unknown. STC2 potently inhibits the proteolytic activity of the growth promoting metalloproteinase, pregnancy associated plasma protein-A (PAPP-A). Proteolytic inhibition requires covalent binding of STC2 to PAPPA, and is mediated by a disulfide bond, which involves Cys120 of STC2. Binding of STC2 prevents PAPP-A cleavage of insulin-like growth factor binding protein (IGFBP)-4 and hence release within tissues of bioactive IGF, required for normal growth. Concordantly, STC2 efficiently inhibits PAPP-Amediated IGF receptor signaling in vitro, and that transgenic mice expressing a mutated variant of STC2, STC2(C120A), which is unable to inhibit PAPPA, grow like wild-type mice. STC2 is a novel proteinase inhibitor and a previously unrecognized extracellular component of the IGF system.1
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nREFERENCES
n1. Malene R. Jepsen, S?ren Kl?verpris , Jakob H. Mikkelsen , Josefine H. Pedersen, Ernst-Martin Füchtbauer, Lisbeth S. Laursen, and Claus Oxvig JBC Papers in Press. Published on December 22, 2014 as Manuscript M114.611665.
- 產品描述
- The PAPP-A Stanniocalcin-2 Complex enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A Stanniocalcin-2 Complex in human serum and other biological fluids.
- 產品特點
- 保存建議
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是開發和生產免疫檢測試劑盒和定制生物技術檢測產領創者，總部位于美國休斯敦，公司產品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術， 以及多年經驗生物技術研發經驗的科學家團隊，產品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。
Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產品研究和新型免疫檢測技術的先驅者。優勢產品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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